Component Research

This is the summary of the activities of each component of bark oil published in medical and scientific journals.  This research is laboratory based, and therefore is not evidence of its actual therapeutic effect in humans, only an indication of the possibility of such. The only human clinical trial was for human papilloma virus (HPV)

Name 

trans-Nerolidol

 

 

 

alpha-Muurolol (=Torreyol)

Bicyclogermacrene

 

 

Spathulenol
 

gamma-Cadinene

 

delta-Cadinene

 

1,10-di-epi-Cubenol

Undeca-1,3,5-triene

 

alpha-Cadinol

 

Germacrene D

 

alpha-Pinene

    

Germacrene B

beta-Sesquiphellandrene

 

Bulnesol

 

 

Viridiflorol

 

delta-Elemene

 

Guaiol

 

 

 

Globulol

 

 

Viridiflorene (Ledene)

 

gamma-Elemene

 

beta-Phellandrene

 

alpha-Muurolene

 

beta-Elemene

 

Alloaromadendrene

 

Aromadendrene

 

alpha-Copaene

 

trans-beta-Farnesene

Uses

 

antibacterial, antifungal, anti-inflammatory, anti-cancer, anti-tumor, anti-ulcer, antioxidant, anti-parasite (schistosomal, leishmanal, other), skin penetration enhancer, disease treatment (chagas, malaria, parkinson's), pain relief (anti-nociceptive), anti-biofilm (vs. surface-bacteria), AKI treatment (acute kidney injury), prevents ALI (acute lung injury) and damage from pneumonia, anti-seizure/epilepsy; cures HPV; insecticidal (mosquito), treats anxiety and depression; reduces damage from heart attacks ; neuroprotectant; liver protection

Details of potential therapeutic activities of nerolidol

antibacterial, antimicrobial; antioxidant; anti-cancer; anti-parasite, anti-tumor

anti-fungal; anti-cancer (breast, cervical, colon, skin, brain); anti-parasite; anti-tumor;

antioxidant, anti-inflammatory, antiproliferative, antimycobacterial, anticancer (gastric, leukemia, colon), leukemia, antiparasite (anti-malarial), antifungal; tuberculosis treatment; mosquito repellent; immunomodulatory; uterus relaxant

anti-ulcer

women's health, anti-microbial, inhibit ovarian cancer

anti-cancer

cancer detection

fungicide, anti-cancer, hepatitis prevention, anti-inflammatory

anti-microbial, anti-inflammatory, antioxidant; tuberculosis treatment

anti-cancer, schizophrenia treatment, antibacterial, bronchitis treatment, anxiolytic, tumor treatment, antimicrobial

cancer treatment (ovarian, lung, colon, stomach, and melanoma), tumor treatment, antimicrobial, insecticidal, antibacterial

antifungal, anti-cancer, antioxidant

anti-cancer (lung), anti-inflammatory, cellular membrane stabilizer

anti-cancer (stomach), anti-inflammatory, antioxidant, tuberculosis treatment, Acetylcholinesterase inhibitor

anti-tumor, anti-cancer (lung, pancreatic, colon)

diuretic, laxative; antiparasitic; antibacterial; insecticide (termites); cancer treatment (lung); anti-inflammatory (treats/minimizes ankylosing spondylitis)

antimicrobial, antibacterial, antifungal, antioxidant, sedative, anaesthetic

tuberculosis treatment; tumor treatment

insecticidal, antimicrobial, and antioxidant

treats dermatitis, anti-fungal, antioxidant

anti-inflammatory

anticancer

antineoplastic, antioxidant

antibacterial, antioxidant, antiaging

antibacterial, antidermatophytic

aphid alarm pheremone, mosquito larvicide, antibacterial

Additional research on details of potential therapeutic activities of nerolidol

Below are links to the scientific and medical articles which support the above summaries

Name 

 

​​​​​​​​​​​​

​gamma-Cadinene

delta-Cadinene

1,10-di-epi-Cubenol

Undeca-1,3,5-triene

 

alpha-Cadinol

 

​​​Germacrene D

 

alpha-Pinene

 

Germacrene B

beta-Sesquiphellandrene

 

Bulnesol

 

Viridiflorol

 

delta-Elemene

 

Guaiol

 

Globulol

 

Viridiflorene (Ledene)

 

gamma-Elemene

 

​beta-Phellandrene

 

alpha-Muurolene

 

beta-Elemene

 

Alloaromadendrene

 

Aromadendrene

 

alpha-Copaene

 

trans-beta-Farnesene

Reference

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669120/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525816/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599884/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848531/

https://www.ncbi.nlm.nih.gov/pubmed/26692745

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384920/

https://www.ncbi.nlm.nih.gov/pubmed/27534132

https://www.ncbi.nlm.nih.gov/pubmed/21872895

https://www.ncbi.nlm.nih.gov/pubmed/30671730

https://www.ncbi.nlm.nih.gov/pubmed/30660710

https://www.ncbi.nlm.nih.gov/pubmed/22224302

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294613/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743669/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699265/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268287/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741888/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268778/

https://www.ncbi.nlm.nih.gov/pubmed/15165160

https://www.ncbi.nlm.nih.gov/pubmed/23307235

https://www.ncbi.nlm.nih.gov/pubmed/30543916

https://pubchem.ncbi.nlm.nih.gov/pathway/PlantCyc:PLANT_PWY-5733

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143264/

https://www.ncbi.nlm.nih.gov/pubmed/31198053

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479355/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471621/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259104/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320997/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323148/

https://www.ncbi.nlm.nih.gov/pubmed/26057223

https://www.ncbi.nlm.nih.gov/pubmed/27612433

https://www.ncbi.nlm.nih.gov/pubmed/21804218

https://www.ncbi.nlm.nih.gov/pubmed/31005810

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582541/

https://www.ncbi.nlm.nih.gov/pubmed/19881213

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1401-9

https://link.springer.com/article/10.1007%2Fs10298-015-0966-7

https://link.springer.com/article/10.1007%2Fs10086-004-0683-6

https://www.ncbi.nlm.nih.gov/pubmed/27566579?dopt=Abstract

https://link.springer.com/article/10.1007%2Fs10787-017-0328-1

www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400022&lng=en&tlng=en

https://www.ncbi.nlm.nih.gov/pubmed/18569693

https://www.ncbi.nlm.nih.gov/pubmed/22224302

https://www.ncbi.nlm.nih.gov/pubmed/21227474

https://www.ncbi.nlm.nih.gov/pubmed/28353108

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651734/

https://www.ncbi.nlm.nih.gov/pubmed/20646341

https://www.ncbi.nlm.nih.gov/pubmed/28818498

https://pubchem.ncbi.nlm.nih.gov/compound/11142#section=BioAssay-Results

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.200890022

https://www.ncbi.nlm.nih.gov/pubmed/15868411

https://www.ncbi.nlm.nih.gov/pubmed/16563660

https://www.ncbi.nlm.nih.gov/pubmed/24918691

https://www.ncbi.nlm.nih.gov/pubmed/21591991

https://www.tandfonline.com/doi/abs/10.1080/10412905.2000.9699508

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985604/#B75

https://scielo.conicyt.cl/scielo.php?pid=S0717-97072004000200010&script=sci_arttext&tlng=en

https://onlinelibrary.wiley.com/doi/epdf/10.1111/jam.12377

http://europepmc.org/abstract/MED/22427877

https://www.ncbi.nlm.nih.gov/pubmed/26434140