Component Research
This is the summary of the activities of each component of essential oil from branch bark as published in medical and scientific journals. This research is based on animal, laboratory, or computer analysis- and therefore is not evidence of its actual therapeutic effect in humans, only an indication of the possibility of such. The only human clinical trial was for human papilloma virus (HPV).
Top 7 constituents in order (based on gc-ms reports)
Constituent Lo % Hi % Median %
trans-Nerolidol 54.0 64.8 59.4
Bicyclogermacrene 4.0 16.8 10.4
alpha-Muurolol 8.1 12.4 10.2
τ-Cadinol 7.5 11.6 9.6
gamma-Cadinene 2.2 4.0 3.10
δ-Cadinene 1.8 2.6 2.2
Spathulenol 0.4 3.2 1.8
trans-Nerolidol
antibacterial, antifungal, anti-inflammatory, anti-cancer, anti-tumor, anti-ulcer, antioxidant, anti-parasite (schistosomal, leishmanal, other), skin penetration enhancer, disease treatment (chagas, malaria, parkinson's), pain relief (anti-nociceptive), anti-biofilm (vs. surface-bacteria), AKI treatment (acute kidney injury), prevents ALI (acute lung injury) and damage from pneumonia, anti-seizure/epilepsy; cures HPV; insecticidal (mosquito), treats anxiety and depression; reduces damage from heart attacks ; neuroprotectant; liver protection
​
​alpha-Muurolol (=Torreyol)
antibacterial, antimicrobial; antioxidant; anti-cancer; anti-parasite, anti-tumor
​
​Bicyclogermacrene
anti-fungal; anti-cancer (breast, cervical, colon, skin, brain); anti-parasite; anti-tumor;
​
delta-Cadinene
women's health, anti-microbial, inhibit ovarian cancer
​
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525816/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599884/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848531/
​
alpha-Cadinol
fungicide, anti-cancer, hepatitis prevention, anti-inflammatory
​
​
https://www.ncbi.nlm.nih.gov/pubmed/27534132
https://www.ncbi.nlm.nih.gov/pubmed/21872895
​
Germacrene D
anti-microbial, anti-inflammatory, antioxidant; tuberculosis treatment
​
https://www.ncbi.nlm.nih.gov/pubmed/30671730
https://www.ncbi.nlm.nih.gov/pubmed/30660710
https://www.ncbi.nlm.nih.gov/pubmed/22224302
​
alpha-Pinene
anti-cancer, schizophrenia treatment, antibacterial, bronchitis treatment, anxiolytic, tumor treatment, antimicrobial
.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294613/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743669/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699265/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268287/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741888/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268778/
​
Germacrene B
cancer treatment (ovarian, lung, colon, stomach, and melanoma), tumor treatment, antimicrobial, insecticidal, antibacterial
​
https://www.ncbi.nlm.nih.gov/pubmed/15165160
https://www.ncbi.nlm.nih.gov/pubmed/23307235
https://www.ncbi.nlm.nih.gov/pubmed/30543916
https://pubchem.ncbi.nlm.nih.gov/pathway/PlantCyc:PLANT_PWY-5733
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143264/
https://www.ncbi.nlm.nih.gov/pubmed/31198053
​
beta-Sesquiphellandrene
antifungal, anti-cancer, antioxidant
​
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479355/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471621/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259104/
​
Bulnesol
anti-cancer (lung), anti-inflammatory, cellular membrane stabilizer
​
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320997/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323148/
Viridiflorol
anti-cancer (stomach), anti-inflammatory, antioxidant, tuberculosis treatment, Acetylcholinesterase inhibitor
​
https://www.ncbi.nlm.nih.gov/pubmed/26057223
https://www.ncbi.nlm.nih.gov/pubmed/27612433
​
delta-Elemene
anti-tumor, anti-cancer (lung, pancreatic, colon)
​
https://www.ncbi.nlm.nih.gov/pubmed/21804218
https://www.ncbi.nlm.nih.gov/pubmed/31005810
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582541/
https://www.ncbi.nlm.nih.gov/pubmed/19881213
​
Guaiol
diuretic, laxative; antiparasitic; antibacterial; insecticide (termites); cancer treatment (lung); anti-inflammatory (treats/minimizes ankylosing spondylitis)
​
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1401-9
https://link.springer.com/article/10.1007%2Fs10298-015-0966-7
https://link.springer.com/article/10.1007%2Fs10086-004-0683-6
https://www.ncbi.nlm.nih.gov/pubmed/27566579?dopt=Abstract
https://link.springer.com/article/10.1007%2Fs10787-017-0328-1
​
Globulol
antimicrobial, antibacterial, antifungal, antioxidant, sedative, anaesthetic
​
www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400022&lng=en&tlng=en
https://www.ncbi.nlm.nih.gov/pubmed/18569693
​
Viridiflorene (Ledene)
tuberculosis treatment; tumor treatment
​
https://www.ncbi.nlm.nih.gov/pubmed/22224302
https://www.ncbi.nlm.nih.gov/pubmed/21227474
​
gamma-Elemene
insecticidal, antimicrobial, and antioxidant
​
https://www.ncbi.nlm.nih.gov/pubmed/28353108
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651734/
​
beta-Phellandrene
treats dermatitis, anti-fungal, antioxidant
​
https://www.ncbi.nlm.nih.gov/pubmed/20646341
https://www.ncbi.nlm.nih.gov/pubmed/28818498
https://pubchem.ncbi.nlm.nih.gov/compound/11142#section=BioAssay-Results
​
alpha-Muurolene
anti-inflammatory
​
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.200890022
​
Alloaromadendrene
antineoplastic, antioxidant
​
https://www.ncbi.nlm.nih.gov/pubmed/16563660
https://www.ncbi.nlm.nih.gov/pubmed/24918691
​
alpha-Copaene
antibacterial, antidermatophytic
​
https://scielo.conicyt.cl/scielo.php?pid=S0717-97072004000200010&script=sci_arttext&tlng=en
https://onlinelibrary.wiley.com/doi/epdf/10.1111/jam.12377
​
trans-beta-Farnesene
aphid alarm pheremone, mosquito larvicide, antibacterial
​
Additional research on details of potential therapeutic activities of nerolidol
