Component Research
This is the summary of the activities of each component of essential oil from branch bark as published in medical and scientific journals. This research is based on animal, laboratory, or computer analysis- and therefore is not evidence of its actual therapeutic effect in humans, only an indication of the possibility of such. The only human clinical trial was for human papilloma virus (HPV).
Top 7 constituents in order (based on gc-ms reports)
Constituent Lo % Hi % Median %
trans-Nerolidol 54.0 64.8 59.4
Bicyclogermacrene 4.0 16.8 10.4
alpha-Muurolol 8.1 12.4 10.2
τ-Cadinol 7.5 11.6 9.6
gamma-Cadinene 2.2 4.0 3.10
δ-Cadinene 1.8 2.6 2.2
Spathulenol 0.4 3.2 1.8
trans-Nerolidol
antibacterial, antifungal, anti-inflammatory, anti-cancer, anti-tumor, anti-ulcer, antioxidant, anti-parasite (schistosomal, leishmanal, other), skin penetration enhancer, disease treatment (chagas, malaria, parkinson's), pain relief (anti-nociceptive), anti-biofilm (vs. surface-bacteria), AKI treatment (acute kidney injury), prevents ALI (acute lung injury) and damage from pneumonia, anti-seizure/epilepsy; cures HPV; insecticidal (mosquito), treats anxiety and depression; reduces damage from heart attacks ; neuroprotectant; liver protection
alpha-Muurolol (=Torreyol)
antibacterial, antimicrobial; antioxidant; anti-cancer; anti-parasite, anti-tumor
Bicyclogermacrene
anti-fungal; anti-cancer (breast, cervical, colon, skin, brain); anti-parasite; anti-tumor;
delta-Cadinene
women's health, anti-microbial, inhibit ovarian cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525816/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599884/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848531/
alpha-Cadinol
fungicide, anti-cancer, hepatitis prevention, anti-inflammatory
https://www.ncbi.nlm.nih.gov/pubmed/27534132
https://www.ncbi.nlm.nih.gov/pubmed/21872895
Germacrene D
anti-microbial, anti-inflammatory, antioxidant; tuberculosis treatment
https://www.ncbi.nlm.nih.gov/pubmed/30671730
https://www.ncbi.nlm.nih.gov/pubmed/30660710
https://www.ncbi.nlm.nih.gov/pubmed/22224302
alpha-Pinene
anti-cancer, schizophrenia treatment, antibacterial, bronchitis treatment, anxiolytic, tumor treatment, antimicrobial
.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294613/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743669/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699265/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268287/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741888/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268778/
Germacrene B
cancer treatment (ovarian, lung, colon, stomach, and melanoma), tumor treatment, antimicrobial, insecticidal, antibacterial
https://www.ncbi.nlm.nih.gov/pubmed/15165160
https://www.ncbi.nlm.nih.gov/pubmed/23307235
https://www.ncbi.nlm.nih.gov/pubmed/30543916
https://pubchem.ncbi.nlm.nih.gov/pathway/PlantCyc:PLANT_PWY-5733
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143264/
https://www.ncbi.nlm.nih.gov/pubmed/31198053
beta-Sesquiphellandrene
antifungal, anti-cancer, antioxidant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479355/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471621/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259104/
Bulnesol
anti-cancer (lung), anti-inflammatory, cellular membrane stabilizer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320997/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323148/
Viridiflorol
anti-cancer (stomach), anti-inflammatory, antioxidant, tuberculosis treatment, Acetylcholinesterase inhibitor
https://www.ncbi.nlm.nih.gov/pubmed/26057223
https://www.ncbi.nlm.nih.gov/pubmed/27612433
delta-Elemene
anti-tumor, anti-cancer (lung, pancreatic, colon)
https://www.ncbi.nlm.nih.gov/pubmed/21804218
https://www.ncbi.nlm.nih.gov/pubmed/31005810
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582541/
https://www.ncbi.nlm.nih.gov/pubmed/19881213
Guaiol
diuretic, laxative; antiparasitic; antibacterial; insecticide (termites); cancer treatment (lung); anti-inflammatory (treats/minimizes ankylosing spondylitis)
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1401-9
https://link.springer.com/article/10.1007%2Fs10298-015-0966-7
https://link.springer.com/article/10.1007%2Fs10086-004-0683-6
https://www.ncbi.nlm.nih.gov/pubmed/27566579?dopt=Abstract
https://link.springer.com/article/10.1007%2Fs10787-017-0328-1
Globulol
antimicrobial, antibacterial, antifungal, antioxidant, sedative, anaesthetic
www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400022&lng=en&tlng=en
https://www.ncbi.nlm.nih.gov/pubmed/18569693
Viridiflorene (Ledene)
tuberculosis treatment; tumor treatment
https://www.ncbi.nlm.nih.gov/pubmed/22224302
https://www.ncbi.nlm.nih.gov/pubmed/21227474
gamma-Elemene
insecticidal, antimicrobial, and antioxidant
https://www.ncbi.nlm.nih.gov/pubmed/28353108
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651734/
beta-Phellandrene
treats dermatitis, anti-fungal, antioxidant
https://www.ncbi.nlm.nih.gov/pubmed/20646341
https://www.ncbi.nlm.nih.gov/pubmed/28818498
https://pubchem.ncbi.nlm.nih.gov/compound/11142#section=BioAssay-Results
alpha-Muurolene
anti-inflammatory
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.200890022
Alloaromadendrene
antineoplastic, antioxidant
https://www.ncbi.nlm.nih.gov/pubmed/16563660
https://www.ncbi.nlm.nih.gov/pubmed/24918691
alpha-Copaene
antibacterial, antidermatophytic
https://scielo.conicyt.cl/scielo.php?pid=S0717-97072004000200010&script=sci_arttext&tlng=en
https://onlinelibrary.wiley.com/doi/epdf/10.1111/jam.12377
trans-beta-Farnesene
aphid alarm pheremone, mosquito larvicide, antibacterial
Additional research on details of potential therapeutic activities of nerolidol
