Component Research
This is the summary of the activities of each component of bark oil published in medical and scientific journals. This research is laboratory based, and therefore is not evidence of its actual therapeutic effect in humans, only an indication of the possibility of such. The only human clinical trial was for human papilloma virus (HPV)
Name
trans-Nerolidol
alpha-Muurolol (=Torreyol)
Bicyclogermacrene
Spathulenol
gamma-Cadinene
delta-Cadinene
1,10-di-epi-Cubenol
Undeca-1,3,5-triene
alpha-Cadinol
Germacrene D
alpha-Pinene
Germacrene B
beta-Sesquiphellandrene
Bulnesol
Viridiflorol
delta-Elemene
Guaiol
Globulol
Viridiflorene (Ledene)
gamma-Elemene
beta-Phellandrene
alpha-Muurolene
beta-Elemene
Alloaromadendrene
Aromadendrene
alpha-Copaene
trans-beta-Farnesene
Uses
antibacterial, antifungal, anti-inflammatory, anti-cancer, anti-tumor, anti-ulcer, antioxidant, anti-parasite (schistosomal, leishmanal, other), skin penetration enhancer, disease treatment (chagas, malaria, parkinson's), pain relief (anti-nociceptive), anti-biofilm (vs. surface-bacteria), AKI treatment (acute kidney injury), prevents ALI (acute lung injury) and damage from pneumonia, anti-seizure/epilepsy; cures HPV; insecticidal (mosquito), treats anxiety and depression; reduces damage from heart attacks ; neuroprotectant; liver protection
Details of potential therapeutic activities of nerolidol
antibacterial, antimicrobial; antioxidant; anti-cancer; anti-parasite, anti-tumor
anti-fungal; anti-cancer (breast, cervical, colon, skin, brain); anti-parasite; anti-tumor;
antioxidant, anti-inflammatory, antiproliferative, antimycobacterial, anticancer (gastric, leukemia, colon), leukemia, antiparasite (anti-malarial), antifungal; tuberculosis treatment; mosquito repellent; immunomodulatory; uterus relaxant
anti-ulcer
women's health, anti-microbial, inhibit ovarian cancer
anti-cancer
cancer detection
fungicide, anti-cancer, hepatitis prevention, anti-inflammatory
anti-microbial, anti-inflammatory, antioxidant; tuberculosis treatment
anti-cancer, schizophrenia treatment, antibacterial, bronchitis treatment, anxiolytic, tumor treatment, antimicrobial
cancer treatment (ovarian, lung, colon, stomach, and melanoma), tumor treatment, antimicrobial, insecticidal, antibacterial
antifungal, anti-cancer, antioxidant
anti-cancer (lung), anti-inflammatory, cellular membrane stabilizer
anti-cancer (stomach), anti-inflammatory, antioxidant, tuberculosis treatment, Acetylcholinesterase inhibitor
anti-tumor, anti-cancer (lung, pancreatic, colon)
diuretic, laxative; antiparasitic; antibacterial; insecticide (termites); cancer treatment (lung); anti-inflammatory (treats/minimizes ankylosing spondylitis)
antimicrobial, antibacterial, antifungal, antioxidant, sedative, anaesthetic
tuberculosis treatment; tumor treatment
insecticidal, antimicrobial, and antioxidant
treats dermatitis, anti-fungal, antioxidant
anti-inflammatory
anticancer
antineoplastic, antioxidant
antibacterial, antioxidant, antiaging
antibacterial, antidermatophytic
aphid alarm pheremone, mosquito larvicide, antibacterial
Additional research on details of potential therapeutic activities of nerolidol
Below are links to the scientific and medical articles which support the above summaries
Name
gamma-Cadinene
delta-Cadinene
1,10-di-epi-Cubenol
Undeca-1,3,5-triene
alpha-Cadinol
Germacrene D
alpha-Pinene
Germacrene B
beta-Sesquiphellandrene
Bulnesol
Viridiflorol
delta-Elemene
Guaiol
Globulol
Viridiflorene (Ledene)
gamma-Elemene
beta-Phellandrene
alpha-Muurolene
beta-Elemene
Alloaromadendrene
Aromadendrene
alpha-Copaene
trans-beta-Farnesene
Reference
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669120/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525816/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599884/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848531/
https://www.ncbi.nlm.nih.gov/pubmed/26692745
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384920/
https://www.ncbi.nlm.nih.gov/pubmed/27534132
https://www.ncbi.nlm.nih.gov/pubmed/21872895
https://www.ncbi.nlm.nih.gov/pubmed/30671730
https://www.ncbi.nlm.nih.gov/pubmed/30660710
https://www.ncbi.nlm.nih.gov/pubmed/22224302
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294613/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743669/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699265/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268287/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741888/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268778/
https://www.ncbi.nlm.nih.gov/pubmed/15165160
https://www.ncbi.nlm.nih.gov/pubmed/23307235
https://www.ncbi.nlm.nih.gov/pubmed/30543916
https://pubchem.ncbi.nlm.nih.gov/pathway/PlantCyc:PLANT_PWY-5733
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143264/
https://www.ncbi.nlm.nih.gov/pubmed/31198053
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479355/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471621/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259104/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320997/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323148/
https://www.ncbi.nlm.nih.gov/pubmed/26057223
https://www.ncbi.nlm.nih.gov/pubmed/27612433
https://www.ncbi.nlm.nih.gov/pubmed/21804218
https://www.ncbi.nlm.nih.gov/pubmed/31005810
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582541/
https://www.ncbi.nlm.nih.gov/pubmed/19881213
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1401-9
https://link.springer.com/article/10.1007%2Fs10298-015-0966-7
https://link.springer.com/article/10.1007%2Fs10086-004-0683-6
https://www.ncbi.nlm.nih.gov/pubmed/27566579?dopt=Abstract
https://link.springer.com/article/10.1007%2Fs10787-017-0328-1
www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400022&lng=en&tlng=en
https://www.ncbi.nlm.nih.gov/pubmed/18569693
https://www.ncbi.nlm.nih.gov/pubmed/22224302
https://www.ncbi.nlm.nih.gov/pubmed/21227474
https://www.ncbi.nlm.nih.gov/pubmed/28353108
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651734/
https://www.ncbi.nlm.nih.gov/pubmed/20646341
https://www.ncbi.nlm.nih.gov/pubmed/28818498
https://pubchem.ncbi.nlm.nih.gov/compound/11142#section=BioAssay-Results
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.200890022
https://www.ncbi.nlm.nih.gov/pubmed/15868411
https://www.ncbi.nlm.nih.gov/pubmed/16563660
https://www.ncbi.nlm.nih.gov/pubmed/24918691
https://www.ncbi.nlm.nih.gov/pubmed/21591991
https://www.tandfonline.com/doi/abs/10.1080/10412905.2000.9699508
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985604/#B75
https://scielo.conicyt.cl/scielo.php?pid=S0717-97072004000200010&script=sci_arttext&tlng=en
https://onlinelibrary.wiley.com/doi/epdf/10.1111/jam.12377