Summary:

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This study revealed that NRD inhibited proliferation and induced apoptosis in U-251 cells. Nerolidol also induced apoptosis by stimulating pro-apoptotic proteins and inhibiting anti-apoptotic proteins. Indeed, NRD triggered apoptosis and cell cycle arrest via p38-MAPK stimulation. This pathway could be intricately linked with the antitumor action of NRD in U-251 cells. Hence, NRD is a promising natural anticancer and chemopreventive agent for GBM. However, in vivo studies are needed to understand the apoptosis mechanism and cell-cycle regulation induced by NRD in GBM cells.

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