Research Articles

Due to differences in animal/human physiology the findings of in vivo studies cannot be translated to effects on human health. In vitro studies on cell cultures also do not guarantee results in humans.

Findings may be an indicator of potential results in humans. Clinical trials are needed to verify extrapolations from laboratory tests.

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Category	Component	Body System	Type	Title
Disease	Nerolidol	Nervous System	In Silico	Nerolidol and its Pharmacological Application in Treating Neurodegenerative Diseases: A Review
Inflammation	Nerolidol	Liver	In Vivo	Downregulation of hepatic fat accumulation, inflammation and fibrosis by nerolidol in purpose built western-diet-induced multiple-hit pathogenesis of NASH animal model
Cancer	Nerolidol	Colon	In Vivo	Inhibition of azoxymethane-induced neoplasia of the large bowel by 3-hydroxy-3,7,11-trimethyl-l,6,10-dodecatriene (nerolidol)
Men's Health	Nerolidol	Reproductive	In Vitro,In Vivo	Effects of chemotherapeutic agents on male germ cells and possible ameliorating impact of antioxidants
Antibacterial,Skin Permeation	Nerolidol	N/A	In Vitro	Effects of nerolidol and limonene on stratum corneum membranes: A probe EPR and fluorescence spectroscopy study
Antibacterial	Nerolidol	N/A	In Vitro	Selection of nerolidol among a series of terpenic and phenolic compounds for its potent activity against Lactobacillus fermentum ATCC 9338
Antibacterial	Nerolidol	Colon	In Vitro	Sensitivity of pathogenic and commensal bacteria from the human colon to essential oils
Enzymes	Nerolidol	Liver	In Vitro	Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver
Women's Health	Nerolidol	N/A	In Vivo	Subfertile Female Androgen Receptor Knockout Mice Exhibit Defects in Neuroendocrine Signaling, Intraovarian Function, and Uterine Development But Not Uterine Function
Synergy,Metabolism	Nerolidol,β-caryophyllene	N/A	In Vivo	The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo
Women's Health	Nerolidol	N/A	In Vivo	The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model
Antibacterial	1,10-di-epi-Cubenol	N/A	In Vitro	Composition of Three Essential Oils, and their Mammalian Cell Toxicity and Antimycobacterial Activity against Drug Resistant-Tuberculosis and Nontuberculous Mycobacteria Strains
Anti-oxidant	Nerolidol	N/A	In Vivo	Antioxidant Effects of Nerolidol in Mice Hippocampus After Open Field Test
Antiparasitic	Spathulenol	N/A	In Vitro	Biological Activities of the Essential Oil from Erigeron floribundus
Cancer	Spathulenol	Lung,Skin	In Vivo	Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil
Cancer	Bicyclogermacrene,Spathulenol	N/A	In Vitro	Chemical Profile and in vitro Biological Activities of Essential Oils of Nectandra puberula and N. cuspidata from the Amazon
Covid-19	Bicyclogermacrene,β-caryophyllene	Lung	In Silico	Recognition of Natural Products as Potential Inhibitors of COVID‑19 Main Protease (Mpro): In‑Silico Evidences
Antifungal	Bicyclogermacrene	N/A	In Vitro	Biciclogermacreno, resveratrol e atividade antifúngica em extratos de folhas de Cissus verticillata (L.) Nicolson & Jarvis (Vitaceae)
Antiparasitic	Bicyclogermacrene	N/A	In Vitro	Chemical composition and in vitro cytotoxic and antileishmanial activities of extract and essential oil from leaves of Piper cernuum
Antiparasitic	Bicyclogermacrene	N/A	In Vitro	In Vitro antileishmania activity of sesquiterpene-rich essential oils from Nectandra species
Antibacterial,Anti-oxidant	Bicyclogermacrene	N/A	In Vivo	Chemical Composition and Antioxidant, Antimicrobial, and Larvicidal Activities of the Essential Oils of Annona salzmannii and A. pickelii (Annonaceae)
Cancer	Bicyclogermacrene	Skin,Brain,Reproductive,Colon,Breast	In Vitro	Chemical composition and in vitro cytotoxic effects of the essential oil from Nectandra leucantha leaves
Antifungal	Bicyclogermacrene,Spathulenol	Skin,Mouth	In Vitro,In Vivo	Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome
Antibacterial	Alpha-Muurolol	N/A	In Vivo	Cytotoxic Effect and TLC Bioautography-Guided Approach to Detect Health Properties of Amazonian Hedyosmum sprucei Essential Oil
Antibacterial	Alpha-Muurolol	N/A	In Vitro	Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils
Muscle Relaxant	T-Cadinol	All	In Vitro	T-cadinol: a pharmacologically active constituent of scented myrrh: introductory pharmacological characterization and high field 1H- and 13C-NMR data