Potential therapeutic effects related to Covid-19
CDC treatment guidelines are located here
Research shows that nerolidol inhibits Interleukin-1β in vitro and in vivo:
Nerolidol inhibits the LOX-1 / IL-1β signaling
"The administration of nerolidol reduced the severity of fungal keratitis with infiltration of fewer inflammatory cells and reduced levels of the LOX-1, as well the anti-inflammatory cytokines such as IL-1β"
Nerolidol Protects Against LPS-induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Signaling- https://pubmed.ncbi.nlm.nih.gov/28093813/
"Nerolidol notably inhibited the increase of TNFα and IL-1β"
Nerolidol exhibits antinociceptive and anti-inflammatory activity: involvement of the GABAergic system and proinflammatory cytokines
"Nerolidol reduced production of interleukin 1 beta (IL-1β) in LPS-stimulated, peritoneal macrophages."
Effect of nerolidol on cyclophosphamide-induced bone marrow and hematologic toxicity in Swiss albino mice
"biochemical analysis revealed increased malondialdehyde (MDA), tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-1β levels and reduced superoxide dismutase (SOD), catalase (CAT), and IL-10 levels (from cyclophosphamide). Treatment with NER significantly reversed the hematotoxic and myelotoxic aberrations ( and retained the structural integrity of bone marrow."
Computer models indicate nerolidol has very good potential to inhibit Tyrosine Kinase:
Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils
"The best docking energies were observed with thymol and (E)-nerolidol (-79.8 kcal.mol-1), which suggested H-bonding interactions with Met281 and His263 (thymol) and His259, His263 ((E)-nerolidol)."
Devil's club essential oil (branch bark) contains more than 50% nerolidol and based upon published studies and CDC treatment guidelines is eligible to be a candidate for clinical trials for treatment of Covid-19.
Suppresses inflammation during lung injuries
Nerolidol Suppresses the Inflammatory Response during Lipopolysaccharide-Induced Acute Lung Injury via the Modulation of Antioxidant Enzymes and the AMPK/Nrf-2/HO-1 Pathway
Antiviral agents in essential oils to treat SARS-CoV-2 (computer projection)
Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation
Computer molecular docking projection shows the strong potential of nerolidol for inhibiting viral replication and infection
COVID‑19 and therapy with essential oils having antiviral,
anti‑inflammatory, and immunomodulatory properties
Devil's club essential oil (branch bark) has the potential to treat or pretreat for conditions caused by vaccine injury
Vaccine injuries reported announced by the CDC
VAERS database https://vaers.hhs.gov/data.html
Injury: Myocarditis/heart related (55k+)
Preventive effect of nerolidol on isoproterenol induced myocardial damage in Wistar rats: Evidences from biochemical and histopathological studies
"Pretreatment with NRD at different doses (100 and 200 mg/kg b.w) for 21 days prevented the above changes induced by ISO. The 200 mg/kg b.w of NRD was more pronounced than the other dose and brought back all the above parameters near to normalcy."
No medical claims or recommendations are being made here. This is merely a summary of the data published on government websites as it relates to the devil's club EO primary component nerolidol and potential treatments - and the repeating of requests by numerous researchers for clinical trials.